P'yatykop G. Clinicomorphofunctional characteristics of Thyrotoxic Enteral Syndrome in Surgical Treatment of Patients with Thyrotoxic Goiter (Clinicoexperimental Assessment)

The work presents the results of ascertaining peculiarities of clinical course of diffuse toxic goiter complicated by enteral syndrome, morphofunctional changes in the small intestine in experimental thyrotoxicosis and in thyrotoxicosis patients. The assessment revealed enzymatic activity decrease in rats' amylase and lipase in exogenous hyperthyroidism and in patients with diffuse toxic goiter. Membranous hydrolysis demonstrated the most remarkable impairments due to decreasing synthesis of enterocytaric enzymes. Morphologic changes manifested themselves as column epitheliocytes dystrophy, polymorphocellular infiltration in the stroma of mucous membrane and its swelling, interepithelial lymphocytes amount increase. Some methods of medicamental correcting digestive function of the small intesting at the stages of surgical treating the patients with thyrotoxic goiter have been developed.