Bereznyak K. Influence of hydration on stability of helical forms of nucleic acids with different AT/GC - composition

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U002115

Thesis Registration Form

0400U002115.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

22-06-2000

Specialized Academic Board

Д 64.051.13

V.N. Karazin Kharkiv National University

Essay

Nucleic acids (NA) with different АТ/GC-composition. To estimate the contributions of different types interactions to enthalpy of NA stabilization. By the methods of IR-spectroscopy and piezogravimetry structural transitions intervals of NA are determined and their thermodynamic description is carried out. It is found that the basic stabilization factor is hydration environment.The influence of low temperatures on DNA structural state and its hydration environment is investigated. Usage area: molecular biophysics, cryobiology.

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