Kozheshkurt V. The relationship between the electrical conductivity of biological media with the functional activity

The object of study: electrophysical parameters of biological fluids, solutions of their components, biological tissues and cultures of bone marrow cells as an integral indicator of their state. Objective: to establish the relationship of electrical conductivity as a biophysical characteristic of biological tissues and environments with the functional state of tissues (in particular, proliferation activity, the presence of liver fibrosis) and the qualitative and quantitative composition of their macromolecules (proteins, lipids). Research methods: impedance spectroscopy, mass spectrometry, adsorption spectrophotometry, confocal microscopy, optical microscopy, nonparametric statistics. Scientific novelty: the dependence of the electrical conductivity of a suspension of nanoparticles on their amount in the medium and on the distribution in the suspension has been revealed; it was shown that there is a relationship between the ionic composition, the content of reactive oxygen species, the proliferative activity of bone marrow cells in suspension and electrical conductivity; on the model of colostrum the influence of low and high molecular weight proteins on the electrical conductivity of the solution is shown. Practical value: application in the food industry and pharmacology for the integral assessment of the quality of colostrum and its products, and in biotechnology to assess the characteristics of cell cultures.