Shcherbakova A. Physical mechanisms of interaction of phenazine dyes with nucleic acids

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U002234

Thesis Registration Form

0400U002234.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

06-07-2000

Specialized Academic Board

Д 64.051.13

V.N. Karazin Kharkiv National University

Essay

Phenazine derivatives, DNA, decathymidylate modified by phenazine glycoside, oligo- and polynucleotides. The work is aimed to stady interaction of phenazines with DNA. By polarized fluorescence method it was shown that the interaction of phenazines with DNA is occurred by intercalation. By the thermal denaturation method using absorbance and fluorescence technique it was shown that the covalent attachment of phenazine glycoside to decathymidylate stabilizas its duplex and triplex formations. The fields of application are molecular biophysics and pharmacology.

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