Sydorenko V. Properties of GABA-activated ionic currents within somatic membrane of isolated rat DRG neurons.

The thesis is devoted to investigation properties of GABA-activated ionic currents in somatic membrane of rat DRG neurons. Obtained data indicate that dependence of maximal amplitude of currents versus concentrations of extracellular GABA in a range of 10 mkM - 2 mM is fitted by Hill’s equation with parameters: EC50 - 343 mкМ and Hill’s coefficient - 2,79. Ionic current, activated both by short and long GABA superfusion, demonstrated complicate kinetiks rise and decay, which could be fitted by two exponents. The dependence of blocking action of bicuculline on GABA-activated currents in somatic membrane of neurones could be fitted by Hill’s equation with parameters: EC50 – 203 nM and and Hill’s coefficient – 1. The density of GABA-activated currents in somatic membrane of DRG neurones are relatively high that allows to assume that GABA modulate of sensory signals.