Tsytsyura Y. Pharmaco-biophysical properties of the nonselective muscarinic cationic current in guinea-pig ileal smooth muscle cells.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U003113

Thesis Registration Form

0400U003113.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

14-11-2000

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

The dissertation is devoted to pharmacological and biophysical characterization of nonselective muscarinic cationic current in guinea-pig ileal SMCs. High [Ca2+]і evoked rapid Ca2+-dependent desensitization of muscarinic receptors; biophysical properties of cationic current were studied with different steady [Ca2+]і. SK&F 96365 blocks cationic current in potential-dependent manner. Usage of this blocker implies that the same type of channel works under depolarization and hyperpolarization. It was found that proteinkinase G blocking causes an increase of the amplitude of carbachol-evoked cationic current and contraction.

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