ABU N. Asymptomatik myocardial ischemia in patients with essential hypertension etiology of disease, the influence of hypotensive therapy

It was examined in dynamis - before the beginni- ng and after 4 weeks of the treatment 158 patients and after 6 month - 76 patients with essential hyper- tension of the II degree. It was established the relation between the daily profile of the AP and the frequency and the expressiveness of the episodes of symptomatic and asymptomatic myocardial ischemia,which were determined during the daily ECG monitoring. It was shown that the frequency and the expressiveness of myocardial ischemia were growing in accordance with the rise of myocardial hypertrophy, the damage of left ventricular systolic and diastolic functions. It was found out the role of ST-associated parameters of ECG during the bicycle ergometer probe in diagnostic of the absolute and relative co- ronary insufficiency. Antiischemic action of Losartan was studied for the first time. In was established that Renitec and Losartan were both effective in angina and asympto matic myocardial ischemia, particular when they resulted from rela tive coronary insulliciency. Diltia- zem had antianginal effect, but it rose the frequency and expressiveness of asymptomatic ischemic episo- des.