Tsyvkin V. Dependence of the coupling of dopamine receptors to G-proteins on the redox state of sulfhydryl groups of the membrane proteins in the molluscan nervous system

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U000403

Thesis Registration Form

0401U000403.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

30-01-2001

Specialized Academic Board

Д26.198.01

Essay

It has been shown that in the plasma membranes from the nervous system of mollusc Lymnaea stagnalis the functional interaction of dopamine receptors with G-proteins is coupled both with stimulation, and attenuation of G-proteins' activity. Inhibition of G-proteins occurs as result of their stabilization in an inactive GDP bound form. Reduction of sulfhydryl groups of membrane proteins enhances the inhibitory action of dopamine receptors on G-proteins and nitrosylation led to their uncoupling.

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