Ergyush N. Disorders of mineral and vitamin homeostasis in differential diagnostics of multiple sclerosis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U000800

Thesis Registration Form

0401U000800.pdf

Applicant for

Specialization

  • 14.01.15 - Нервові хвороби

21-03-2001

Specialized Academic Board

Д 26.613.01

Shupyk National Medical Academy of Postgraduate Education

Essay

The dissertation is devoted to the study of features of the changes of mineral and vitamin composition of blood in multiple sclerosis patients depending on sex, age, clinical course, severity and duration of the disease, and also comparison of these parameters with such as the patients with other organic diseases CNS (strokes, tumors, arachnoiditis). The detected magnification ofZn, Cu, Mn, Fe and Ni content of blood in MS patients indicates to the increase of the antioxidant protective system of the organism. The increase of concentration of a Cr, Si, Mo, Ca, Ma and Ті specifies the loss of these elements by the tissues in MS. Taking into account their antioxidizing properties and considering blood as an intermediate system it is necessary to suppose, that the redistribution indicated trace elements between the organs results in a diminution of the reserve of non-fermentative link of the antioxidant defense in the tissues. The magnification of concentration in blood of Al, Pb, Ag, V, Ba, Y, Sr testifi es about directed decompartmentilization of these elements, by reducing their prooxidant effect in the tissues in MS, and revealing of Cd, Co, Sn in blood having also prooxidant properties, allow to assume that their redistribution between the organs, which could potentially act in a role of the factors of infringing the prooxidant-antioxidant balance in the tissues, and their income to the blood indicates the buffer function of blood in oxidizing homeostasis of the organism. The parameters of modification of the mineral spectrum of blood can be used for differential diagnostics of MS with cerebral arachnoiditis, strokes and brain tumors. In blood of the patients of the indicated groups the levels ofZn and Al was reliably increased, and at the patients cerebral arachnoiditis and brain tumors the level ofCu, Mn, Ni, Si was identically increased, and Mo - was reduced. The content of Ті was reliably increased, and Fe, on the contrary, was reduced only in the blood of the patients with brain tumors and strokes. T he level of Ag was increased, and Ca and Zr were reduced at the patients with cerebral arachnoiditis and strokes. Various of quantitative modifications ofBa and Sr concentrations were established: in cerebral arachnoiditis - the Magnification, and in strokes - the reduction. The content of Mg was reliably increased, and Si and Cu were reduced only in the blood of the patients with strokes. In the blood of MS patients the reliably increase of thiamin concentration in initial period of the disease and decrease of ascorbic acid and the contents of vitamin A, E and PP did not differ from the estimated datas. Also the concentration levels of vitamin В1, С and PP were decreased in patients with cerebral arachnoiditis, strokes and brain tumors. The outcomes of the conducted researches testify that the features of the modifications of mineral and vitamin homeostasis in MS expand not only pathogenesis aspects of the demyelinization pathology, but also can be used for perfecting the diagnostics of this disease, and als o for differential diagnostics of MS and other organic diseases CNS and, besides open a new approach in search of effective paths of preventive maintenance and treatment of this progressing disease of the nervous system. The trouble-shooting test for differential diagnostics of MS is revealed. The obtained data enable more deep understanding the development peculiarities of the demyelinization process, and also improvement of the methods ofpharmacological corrections of metabolic disorders by antioxidant drugs in combination with the trace elements.

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