Lafarenko V. Therapeutic effect of the opiate antagonists in experimental hemorrhagic shock

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U001015

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

30-03-2001

Specialized Academic Board

К 58.601.01

Essay

Acute experiments on 81 adult rabbits aimed at elucidation of effects of opiate antagonists and blood reinfusions in hemorrhagic shock (US) demonstrate that intravenous injection of naloxone or nаlorphine in the different periods of hemorrhagic shock speeds up the death of the animals. It was concluded that in hypoxia conditions antagonistic activity of preparations take place. This results in the loss of the opioid system protective properties. Nalorphine, injected after the blood reinfusion, displays agonizing activity and the additional activation of endogenic opioidic system promotes the organism to use its biological reserves, which leads to survival of some animals or significant increase of life duration of the others.

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