Fisyunov O. Hyperforin modulates of P-type calcium channels in Purkinje neurons

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U001642

Thesis Registration Form

0401U001642.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

22-05-2001

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

Extracellular application of hyperforin from 0.04 to 0.8 mkM induced a shift the maximum of the current/voltage (I/V) relationship from -2 to -10 mV, a profound deceleration of the current activation kinetics and significant inhibition of the amplitude of P-current. Calmidazolium (0.5 mM), the antagonist of intracellular Ca2+-binding protein calmodulin inhibited the hyperforin-induced shift the maximum of I/V curve and the slow-down of the activation kinetics.

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