Bryzyts'ka O. Synthesis, cevical transformations and biological activity of (-aminocaproic and succinic acids

A nevw grup of biologically active (-aminocaproic acid derivatives such as N-arylsulfono-(-aminocaproic acids, their sodium, potassium and glucosylaminonium salts, chloroanhyddrides, methyl esthers, amides, hydrazides, N-arylsulfonocaprolactams and N-arylsulfono-(,(-dichlorcaprolactams has been synthesized. The chemical properties of N-arylsulfonocaprolactams in the reactions with nucleophilic and electrophilic reagents have been investigated. A preparative syntetic method of 2-arylsulfamidopentylbenzimidazols and arylsulfonohydrazides of (-(2-benzimidazolyc)propionic acid by the interaction of N-arylsulfonocaprolactams and N-arylsulfonoamidosuccinimides with o-phenylendiamine has been suggested. The pharmacological screening of the compounds synthesized has been performed. N-(4-nitrobenzolsulfono)-(-aminocaproic acid revealing a high hemostatic and amarked reparative activity has been recommended for burther pharmacological studies. At also has a positive influence on hemopoiesis