Bihdan O. Synthesis, chemical modification and biological properties of 3-, 4, 5-trisubstituted-1,2,4-triazole-3-thions

The presented dissertation work is a complex fundamental research. According to the results of a comprehensive test, a series of new biologically active compounds were identified among the new 3-, 4-, 5-trisubstituted-1,2,4-triazole-3-thions. New, and sometimes optimized, known conditions for a number of chemical transformations have been proposed, physicochemical properties of synthesized substances have been studied, and a number of compounds with high biological properties have been identified. A «leader compound» was identified, for which the anti-inflammatory effect was studied in a model of experimental pancreatitis in rats. The effect of morpholine 2-((5-(3-fluorophenyl)-1,2,4-triazole-4-amino-3-ylthio)acetate on the growth, development and yield of grain sorghum in the field was experimentally studied grain sorghum yield indicators in relation to the control group. According to the results of the research, the quality of the substance 3-(3-fluorophenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazine (4.66) in accordance with the requirements of the SPU using analytical methods of qualitative and quantitative determination. For the substance 3-(3-fluorophenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]-triazolo-[3,4-b][1,3,4]thiadiazine (4.66) developed and approved in the prescribed manner technical conditions (TU) «3-(3-fluorophenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazine pure» TU U 20.1-42067827-002: 2021, laboratory method of synthesis of intermediate product and final substance, as well as research and production technological regulation of substance production.