Safonov A. Синтез, перетворення, фізико-хімічні і біологічні властивості похідних 1,2,4-триазолу, які містять тіофен-2-ілметильний замісник

The dissertation is a complex scientific work devoted to the search for biologically active compounds among 1,2,4-triazole derivatives that contain a thiophen-2-ylmethyl substituent and the creation of a new, original medicinal product with actoprotective and stress - protective effects. It was obtained a database for antimicrobial (92/2), antifungal (92/9), antituberculosis (1/1), analgesic (13/2), antihypoxic (40), diuretic (17), actoprotective (53/9), antiradical (10/2), antioxidant (10/1) activity of 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-thiol and 3-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5-thiol derivatives with establishing the correspondence of the biological effect to the functional groups of the synthesized substances. The methods of quality control for the potential substance sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetate for the manufacture of non-sterile forms has been developed.