Babich Y. Visualisation of the skin spatial&temporal electrical parameters to reveal their characteristic changes.

The dissertation is devoted to developing a novel technology of medical imaging, i.e. an instrumental&methodological basis for visualisation the skin spatial and temporal electrical parameters (SSEP). An original primary SSEP transformer and its modifications were developed which based on specially elaborated raster electron-beam converter tubes with a multimicroelectrode matrix as a target. The opposite side of the matrix is to be put in contact with the skin area of interest. Readout parameters: module of impedance at 2 kHz and 1 MHz, argument at 2 kHz, potential. Spatial resolution < 0.5 mm, scan time < 30 s (at the 20ґ40 mm2 scan area). The developed primary transformer was used for elaborating a proper measurement&information system ("MIS SSEP"). An influence of various measurement factors at the SSEP reproducibility have been investigated. A few reliable and very sensitive statistical signs to detect a very small, unseen changes in the SSEP image sequences have been found out. Specifically, it be came possible not only to reveal the SSEP response to a 20-30 s. holding one's breath, but also to differentiate intercellular from intracellular induced processes; input of the d.c. as small as 0.001 mkA/mm2 produced marked changes of the SSEP. For the first time, there have been revealed, monitored and described some biologically active skin zones (pain projections, hyperaesthesy, acupuncture points). Phenomena of the SSEP spatial&temporal structuring have been disco-vered: an initial solitone autowave at the SSEP; mechanically and non-thermal mm-EMF induced autowaves: non-stationary spliting of the SSEP response to a directed mechanical irritation. Hypothesis of calcium waves of intra- and inter-cellular signalling as an origin of the observed effects has been proposed and analysed. The elaborated technology may be used for modernisation of various bio-medical methods, e.g. in the fields of neurology, dermatology, electropuncture diagnostics, electrical bioimpedance tomography. Discovered effects make i t possible to develop new methods of: earlier diagnostics, controlled therapy of any type, investigation of the electromagnetic' and other factors' influence on the organism.