Sorokina O. The influence the drugs for regional anesthesia on adaptive abilities of functional state of cardiovascular system in patients undergoing urology surgery experimental clinical investigation)

The thesis is devoted to research of various local anesthetics and agents for epidural anesthesia effects on cardiovascular system functional state and it's adaptation-compensatory abilities in elder patients having urological surgery. Experimental part of the research study enlightens neurophysiological characteristics of animal spinal cord functioning in presence of chinoxycaine, bupivacaine and lidocaine, their duration of action and reversibility of effects. There was established the most informative spectral parameters in cardiac rhythm variability evaluation. Possible applications of transoesophageal electric stimulation of the left atrium have been studied for preoperative diagnosis of ischemic coronary disease in elder patients without clear clinical manifestation. Under the scope there were electrophysiological changes of heart conducting system during the course of epidural anesthesia.