Mzugi I. Proteinase-inhibitor system in the development of acute lung injury in patients with complicated abdominal pathology and grounding of pathogenetic intensive therapy

28 patients with acute abdominal pathology and experimental animals with model of postischemic toxemia. The aim of investigation - to study the proteolytic enzymes and their inhibitors role in the development of acute ling injury under emergency conditions and grounding new approaches for improving of pathogenesis prophylactics and intensive care. Clinical, biochemical methods for proteolytic enzymes and their inhibitors detection, investigation of morphology, cytochemistry electronnomicroscopy and statistics were used as well. There was found new pathogenesis aspects which lead to development of lung injury under emergency conditions. There was grounded the conception of one way changes of components of proteinase inhibitors system in different regions of the body. In experimental studies there was found perspective approach of prevention and treatment broncho-lung complications under shock, emergency conditions and urgent surgery which includes mutual administration proteinase inhibitor and antioxida nt of flavonoid group The field of application - health protection.