Potapov O. Lung surfactant system and correction of its disturbances by natural surfactant "Sucrim" in patients with acute lung injury syndrome.

28 Patients with acute lung injury syndrome (ALIS). The aim of investigation - to establish changes of lung surfactant system (LS) in patients with ALIS and to study the possibility of their correction with natural surfactant "Sucrim". Clinical, biochemical, biophysical methods, investigation of X-ray dynamic, morphology, electronnomicroscopy and statistics were used as well. The LS disturbances play the important role in development of respiratory failure in this patients. For the improvement results of treatment ALIS and correction of its disturbances was used Ukrainian natural surfactant "Sucrim". It was established that intratracheal injection "Sucrim" lead to improvement functional activity of LS, improvement gas exchange, raising lung compliance and positive X-ray changes. It was established that "Sucrim" prevent to hyaline membranes formation and necrosis in structural components of air-blood barrier. Field of application -health protection.