Antonenko O. Synthesis, properties and application of peroxide derivatives of benzoic acids substituents in pharmaceutical analysis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U000814

Thesis Registration Form

0402U000814.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

22-02-2002

Specialized Academic Board

Д64.605.01

Essay

The synthesis of peroxybenzoic acids and acyles peroxides with the corresponding chlor-, methyl-and mixed chlor-nitro-substituents in benzene ring has been performed. The structure of the compounds obtained has been proved by IR, UV- spectra data computer calculations. Antimicrobial activity of the synthesized compounds has been investigated. Peroxide of n-methylbenzoil has been recommended for further, profound pharmacological studies. A new oxidimetric reagent, perbenzoic acid, has been theoretically substantiated and introduced on the basisof computer calculations. The methods for determination of cycteine, acetylcysteine, ascorbic acid have been worked out, as well as acetylcysteine and ascorbic acid, cysteine and ascorbic acid in individual and combined medicinal forms.

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