Bol'but A. Intramolecular cyclizations of N-alkylidenecarbamic acid derivatives

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U001635

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

16-05-2002

Specialized Academic Board

Д 26.217.01

Institute of Organic Chemistry NAS of Ukraine

Essay

6 scientific works are defended. The works are devoted to study of new intramolecular cyclizations of N-alkylidenecarbamic acid derivatives. For the first time it was shown that the N-alkyliden-О-arylurethanes and N-alkyliden-N'-arylureas cyclized at raised temperature giving derivatives of benzo[1,3]oxazinones and 2-quinazolinones correspondingly. On the base of N-aryl(heteryl)-N'-methoxycarbonyltrihaloacetamidines cyclocondensations the new synthetic methodology of previously unknown fused pyrimidine systems bearing trihalomethyl group such as benzo[h]- and benzo[f]quinazolinones, furo[2,3-d]pyrimidin-4-ones, thieno[2,3-d]pyrimidin-4-ones, pyrazolo[3,4-d]pyrimidin-4-ones, isoxazolo[5,4-d]pyrimidin-4-ones was elaborated.

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