Gnatkovs'kyj V. The role played by excitatory aminoacids and the opiate mechanisms in the resistant forms of epileptic syndrome development

It was shown that postponed period kindling was characterized by susceptibility increasing to DAMGO (2,5 nM, i.c.v.) epileptogenic effects on (i-opiate receptors as well as susceptibility decreasing to k- (dynorphin Al-13) and 5- (DADLE) opiate receptors antiseizure effects stimulation (10,0 nM, i.c.v.). DAMGO (300 nM) together with NMDA (1,0 mkM) administration into the incubative solution in the doses that were ineffective in case of their separate administration to change the spikes parameters resulted in both the first spike amplitude increasing on 47% and the second spike amplitude with 10-ms interval stimulation increasing in 2.7 times pertaining the control data during the postponed kindling. The second spike amplitude with 100-ms interval stimulation increasing on 22%. The same characteristics of the induced activity were shown on the hippocampal slices of the picrotoxin-kindled animals.