Torbinsky A. The hormonal mechanisms of experimental ulcer development in rats and their correction by lipodal

Dissertation sacred to actual medical problems: studying of pathogenesis of ulcerous illness and possibility of pahtogenes flow correction of ulcerous illness attached to help of synthetic analogues neiropeptides. Established, that flow of experimental ulcerous illness by typically native homeostasis changes. Develops a hormonal disbalance: reinforcement of secretion of stress hormones and gastrin with simultaneous secretion oppression of antistress hormones and hormones entero-pancreatic axis. On background of hormonal disbalance develop the considerable metabolism violations. All that brings about considerable trophic violations in mucous envelope with beginnings of ulcers and erosions. Application of diverse officinal forms dalargin (synthetic analogue encefalin) renders correcting influence on hormonal disbalance, for hours together with that conduces to metabolism normalization after counting protective and stimulant action on enzymes antiocsidant defense and transmembran exchange. This displaysin protective, antiulcerous action and repair stimulant of mucous envelope. It was shown that liposomal form dalargin (lipodal) is most effective from preparations dalargin attached to correction of hormonal disbalance and metabolism violations.