Dovganiuk L. Pathogenetic Mechanisms of Renal Dysfunction in case of a Combined Action on the Organism of Chlorous Compounds of Heavy Metals, External and Incorporated Ionizing Radiation

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U001834

Thesis Registration Form

0402U001834.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

31-05-2002

Specialized Academic Board

К 58.601.01

Essay

The dissertation has elucidated general consistent patterns of the functtional - biochemical state of the kidneys, including the principal energy-dependent process of the renal tubules - reabsorption of the sodium ions under conditions of a combined action of heavy metals (plumbum, thallium and cadmium chlorides), external (- and incorporated ionizing radiation on experimrntal animals. In order to achieve further approval, it is recommended to use methods of resolving this pathology, employing thiotriazolinum and ureide of the trans-2,4-dihydroxycinnamic acid (substance X2), whose protective influence is realized via a decrease of lipid peroxidation, an increase of the fibrinolytic and collagenase activity that may be regarded as a possible prevention of tubulo - interstitial fibrosis.

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