Grebenuyk G. The role of external breathing and parameters of oxygen transport system in pathogenesis of chronic cerebrovascular pathology

The object is chronic cerebrovascular pathology; the aim to determine the role of external breathing and parameters of oxygen transport system in pathogenesis of chronic cerebrovascular pathology; the methods are clinical, instrumental, electroneurophysiological, biochemical methods; the new approach lies in complex research of external breathing function and parameters of oxygen transport system at patients with chronic cerebrovascular pathology. Disordered external breathing function as hyperventilation impairments and compensatory reactions to hypoxia in oxygen transport system were revealed. Negative influence of the revealed impairments in external breathing function on clinical manifestation of the disease, electroencephalogram pattern and on the mechanisms of adaptation in oxygen transport system is established. Relation of breathing pattern formation and cerebral hemodynamics condition has been investigated. An increased generation of active oxygen radicals and decreases activity of superoxydedismutase and catalase in erythrocytes is being registration. Differential correction of the revealed impairments in external breathing function with application of instenon and dalargin and respiratory gymnastics is proposed. The results of this research have been provided to work of Kharkiv hospitals