Yarotskyy V. cAMP-dependent mechanism of depolarization of vascular endothelium

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U002737

Applicant for

Specialization

  • 03.00.02 - Біофізика

10-09-2002

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

Іt has been established that increasing of the intracellular cAMP concentration induced the membrane depolarization. It has been shown that cAMP-dependent depolarization is one of mechanisms of the depolarizing that induced by ATP. A noradrenaline-affected depolarization is caused by smooth muscle cells depolarization owing to a1-adrenoceptors activations and endothelium depolarization owing to b-adrenoceptors activation. b-adrenoceptors-activating depolarization is the cAMP-dependent.

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