Shumowa N. Natriuretic hormone and a potassium-sodium metabolism in patients with ishemic heart disease and the disorders of cardiac rhythm

Object of investigation: ishemic heart disease. The aim of the work. Optimization of treatment methods in the patients with ishemic heart disease with arrhythmias using inhibitor angiotensin-converting enzyme and membrane depressant on the base of study of pathogenetic factors (natriuretic hormone and potassium-sodium metabolism). Methods and equipment of research. A clinical method of an estimation of an objective condition of the patient, method of electrocardiography, Holter monitoring.Natriuretic hormone and Na-K-АТPаse - spectrophotometric method. Blood electrolytes (potassium, sodium, calcium, magnesium) - spectrophotometry Hemodynamic parameters - echocardiography. Theoretical and practical results: The contents natriuretic hormone in the patients with ishemic heart disease and arrhythmias (atrial fibrillation, ventricular premature complexes, supraventricular premature complexes) have been studied for the first time. It was established correlation between a level of natriuretic hormone, activity Na-K-АТPase, concentration plasma and erythrocytes electrolytes (potassium, sodium, calcium, magnesium), hemodynamic indexes and types of cardiac rhythm disorders. The method of the combined therapy of inhibitor angiotensin-converting enzyme and membrane depressant was offered. Practical novelty: It is important to the revealed disorders of humoral regulation (increase natriuretic hormone and decrease of activity Na-K-АТPase) in choosing of differential treatment. The inhibitor angiotensin-converting enzyme - invoril was recommended to patients with ishemic heart disease and the disorders of cardiac rhythm particulary ventricular premature complexes and supraventricular premature complexes and combined therapy - inhibitor angiotensin-converting enzyme - invoril and membrane depressant - propafenone in patients with atrial fibrillation, ventricular premature complexes. The increasing of dispersion of interval QT is recomended as marker of risk arrhythmia occurrence. The degree of introduction: The results ofinvestigation were introduced in the hospital of Kharkov and Kharkov region. Sphere of use: Medicine, cardiology.