Kostiuchenko L. Morphofunctional and immunological features of cells and bioсhemical composition of plasma under the influence of ozonation

The influences of different regiments of blood ozonation in vitro on morphofunctional features ofcells, main immuno-logical indexes, biochemical constants of plasma, blood gases balance and the system of haemostasis were investigated. It was found that processing the blood with ozone leads to oxy-gen destruction of blood cells, mostly - the red blood cells, activates the phagocytic activity and oxidizing processes in neutrophils, leads to decrease in C3 and C4 components of complement system, stimulates white blood cells for IL-1b production. Dose-dependent disturbances in blood haemosta-sis due to decreased number of platelets and their depressed aggregation have been shown. Safe concentrations of ozone for investigated regiments of blood ozonation, have been de-termined. Suggested haemolysis parameters and platelets ag-gregation tests were recommended for control in patients re-ceiving ozone therapy.