Smyrnova V. Humoral and cellular mechanisms of adaptation to physical loading at hypertension disease.

The dissertation is devoted to questions of improvement of methods of diagnostics of development and clinical current arterial hypertension on the basis of a complex rating of a status of sympathoadrenal system and level stress - realizing hormons in interrelation with changes of parameters cellular and humoral of immunity in conditions of the simulated stress. The carried out researches have allowed to establish Communication of parameters cellular and humoral of immunity with pressure by an orientation of shifts of activity of sympathoadrenal system, concentration cortyzol and insuline, that testifies to participation of immunity mechanisms in development arterial hypertension already at early stages of disease. On the basis of the carried out complex research in conditions of the simulated stress the latent changes of the immunity status at the patients with arterial hypertension are revealed which are not registered in basis conditions. The way of forecasting of development of hypertensive diseaseis developed on the basis of determined by the author " index of a gain " - relation of a gain of a level noradrenalin to the bicycle- test, executed at a, to work and is shown it prognostic the importance.