Rotova S. The particularity of the disease course and the effect of treatment in glomerulonephritis on the basis of the sort of infection and immune reaction of the patient.

This thesis is dedicated to the study of the factors which are pertaining to the infectional genesis that influence to the course of glomerulonephritis and enhancing the level of it's treatment. In this thesis has been indicated theoretical generalization and also the need for solving the scientifical problems in the zone of enhancing and increasing the effect of medicamentosal treatment of the patients of glomerulonephritis. In this regard there has been shown the accompanying chronic local infection with various localizations, their trigger factors and particularity of the immune system condition, by the purpose of implementing up to dated methods of sanation of organism and the correction of the immune system. It is established that in nephrotic form of acute and chronic glomerulonephritis the important row is played by high level infection of the urine, mucosae tissue of urethra by bacteries, moluqutes, chlamidies and the presence of diagnostical importannt factors, the titres of antibodies launched to the varioral infections, and the basicly proved dependence, the characteristics of the clinical course of the disease and the effectness of the treatment of these indications. It's also been indicated that the acute form of glomerulonephritis often transforms in to the chronic form in patients underwind micoplasmic infection. Under such conditions were there is the presence of the mix - infections, the course of the disease is going to be exacerbated and also the effectness of the treatment for the patients with chronic glomerulonephritis is going to be decreased. It's established that the activation of the beta part of the immunitet while the treatment of acute glomerulonephritis is already accomplished prognosticly is an unsavourable sign and implicates the activness of the process and the possibility of the recurrence or the passage of the disease in to the chronic form. For the first time it's been experimentally proved that the antiagrigant that is dipiridamol stimulates the production of the lateinterferon. There is suggested the complex of methods for investigations of the patients with glomerulonephritis and, as a consequence of which it's possible for prognosing the effectness of the treatment of the patients with nephrotic form of the acute glomerulonephritis.