Ulianov V. The state of thiol-disulfide system and its role in structural violations of liver of brood of irradiated rats

The research of a thiol-disulphide system condition in a liver tissues and blood serum of brood from irradiated before pairing in a doze 0,75 Gy and 1,0 Gy males and females is conducted. The value of balance in thiol-disulphide system for the formation of structural changes of a liver parenhime is investigated. Is established, that in physiological conditions, thiol-disulphide system of liver tissues and blood serum differed at males and females. The long duration (-irradiation called an exhaustion protein and nonprotein links thiol-depending of unspecific resistence system, and at males in the greater degree, than at females. The long duration total (-irradiation males and females before pairing called significant morphofunctional violation in a liver of their brood at all researched stages of ontogenesis. The degree of these changes depended on a sex of animals and doze of irradiation of the predecessors. At males phenotype indicatore of irradiation-stimulated damages of genome are more expressed, than at females.