Tkachenko S. Complex treatment of psoriatically-affected patients considering defects of fibronectin metabolism

Object of the study: 127 psoriatically-affected patients. Purpose: The working out of a new pathogenetically-substaintiated effective method of treatment for psoriasis, which normalizes disturbed metabolism of fibronectin, method of investigation and equipment: clinical, laboratory, immuno-enzymatic, histological, immunomorphological, immunological. Equipment: Torsion scales, spectrophotometer, thermostat, IEA-analyzer, microtome, microscope. Theoretical and practical results: The indexes of the metabolism of fibronectin, immune system, antibodies of the DNA of psoriatically-affected patients have been studied. Summarizing the date obtained a complex method of treatment for psoriasis with gelofusine has been theoretically substantiated and introduced. Gelofusine has proved to be a selective sorbent for fibronectin, which is corroborated by immunoenzymatic analyses. Introduction of the new method makes it possible to improve therapeutic effectiveness of treatment for psoriatically-affected patients, reduce an in-patients stay, prolong the interrelapse period and reduce frequencies of relapses. Introduction: The method of treatment of psoriatically-affected patients has been introduced at Dnepropetrovsk's municipal skin-venereal prophylactic center, at the skin-venereal department of the Central municipal clinical hospital of Kiyv, at the 5-th municipal clinical skin-venereal prophylactic center of Kharkov. Materials of thesis are been used by skin and venereal diseases departments of Kharkov's state medical university, the National medical university after O.O. Bogomolets and in the skin venereal diseases course of the Ukrainian medical stomatological academy.