Byelins'ka I. Morphofunctional parameters of megakaryocytes and platelets attached to myelodysplastic syndromes

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U000381

Thesis Registration Form

0403U000381.pdf

Applicant for

Specialization

  • 03.00.11 - Цитологія, гістологія

27-01-2003

Specialized Academic Board

Д 26.001.38

Taras Shevchenko National University of Kyiv

Essay

The morphology, cytochemical indexes and function parameters, membrane's lipids and ATPases activity of bone marrow megakaryocytes and blood platelet attached to myelodysplastic syndromes were investigated. It was found the increase of number basophilic megakaryocytes and simultaneous reliable decrease in the quantity of polychromatophilic megakaryocytes. Decreasing in number of glikogen, non-specific asterase in megakaryocytes was shown. Changes of megakaryocytes cause the decrease of platelet function. The decrease of Са2+-AТP-ase and increase of Na+,K+-AТP-ase activity couses the decrease of platelet aggregation and apearing of altered megakaryocytes.

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Files

DIS.doc

DIS.doc

aref.doc

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