Sleta I. Action of local cryoinjuries on microhemocirculation of normal and cirrhotically affected liver

The aim of the research was to study local microhemocirculatory response and changes within the blood system following dosed local cryoexposure of normal liver and liver with a CCl4-induced cirrhosis. The experiments were conducted with 189 rabbits and 210 rats. Using the methods of life-time microscopy, luminescent quantitative photometry, thermometry, mathematical modeling of the liver during cryoexposure, the author managed to establish 3 temperature zones in the liver tissue, and to define main trends of pathomorphosis in them: I - zone of freezing, limited with the isotherm of -5 C, in which ischemic necrosis was formed; II - zone of cooling or terminal zone, limited by the isotherms of -5 C and 0 C, in which early microhemocirculatory impairments corresponded to the acute phase of the inflammatory process; III - zone of hypothermia with a temperature above 0oC, in which microhemocirculatory alterations were minor and short-lived. A study of the morphological, biochemical and coagulative featuresof the blood showed that local cryodestruction of the normal liver triggered minor shifts in the functional activity of the liver, which were of transitory nature. Local cryoexposure of the cirrhotically affected liver did not intensify metabolic and structure-functional impairments, related to the occurrence of experimental cirrhosis.