Polonsky A. Catecholamines' metabolism of young rats borned from irradiated animals

Aim of research: study of pathogenetic mechanisms of catecholamines' metabolism's changes of the posterity from the irradiated animals.Object: sympatheticoadrenal system. Methods: chromatographic, radioenzymatic, spectrophotometric, colourimetric. The maintenance of nontypical forms of catecholamines increases in hypothalamus and suprarenal glands of young rats borned from 0,5 Gr irradiated animals. The increase of parents' irradiation dose to 3 Gr causes decrease of epinephrine's maintenance in hypothalamus, epinephrine's and nor- epinephrine's maintenance in suprarenal glands, hypocatecholemia, hypocatecholuria and decrease of catecholamines' maintenance in tissues. The radiosensivity of 1 month aged young rats borned from irradiated animals decreases due to following 1,0 Gr irradiation depend on the increase of the parents' irradiation dose. The catecholamines' biosynthesis decreases, the activity of monoamine oxidase increases, the maintenance of catecholamines decreases in tissues. Exhaustion ofsympatheticoadrenal system increases.