Soldatova, J. Particular features of vegetative homeostasis and therapy of children with mitral valve prolapse.

Dissertation is dedicated to the problem of revealing particular features of vegetative nervous and cardiovascular systems functioning in children with mitral valve prolapse (MVP) and developing upon this basis the therapeutic means aimed to improve patients rehabilitation.The work has first accomplished an all-round research and comparative data analysis as to the functioning of vegetative nervous system, psycho-emotional status as well as functional status of cardiovascular system of children having diverse MVP forms.It was found out that on the background of initial sympathycotonia and a high degree of anxiety a decrease of adaptive and adjustable mechanisms (AAM) and vegetative oversuppy were typical for children having primary MVP while in children with secondary MVP the tension of AAM and lack of vegetative supply as well as higher level of desadaptation by the disease associated with loss of social guiding lines were observed.Children with MVP first revealed initial stages of diastolic dysfunction. Hypovolemic type of the central hemodynamics was determined as well as true decrease in the opening velocity of mitral valve anterior cusp and increase in time index of decreasing the pressure gradient half in mitral blood flow, being more pronouced in children having dynamically significant MVP forms and phenomena of the myxomatous degeneration of mitral valve caps.A new method was developed for early diagnosis of the primary MVP in children using functional furosemidum tests.A scheme for the all-round treatment of children of MVP was elaborated and approved under hospital conditions with metabolic type preparation neoton (creatine phosphate) first applied.It was revealed that normalizing of vegetative homeostasis and improving indexes of systolic and diastolic myocardial function as well as organism's bioenergy state will contribute to reducing MVP degree.