Synchykova O. Effect of amphiphilic compounds on erythrocytes hypertonic haemolysis

There has been investigated the development of red cells' hypertonic hemolysis depending on cell state when changing the temperature and osmotic conditions in the medium, as well as in the presence of amphiphilic compounds. In the work we have investigated positively charged amphiphilic compounds (trifluoperazine and lidocain) as well as nonionic derivatives of glucopyranoside (hexyl-b, D-glucopyranoside, octyl-b, D-glucopyranoside and decyl-b, D-glucopyranoside). The amphiphilic compounds studied significantly reduced the level of red cells' hypertonic haemolysis. Antihaemolytic activity of those is determined by the conditions of hypertonic effect on cells, physical and chemical properties of amphiphile molecules and an initial cell state, formed at the stage of preliminary incubation in the media of moderate tonicity under certain temperatures.