Poluyan S. The chemico-toxicological investigation of Bromhexine and Ambroxole

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U001679

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

25-04-2003

Specialized Academic Board

Д64.605.01

Essay

The Bromhexine and Ambroxole detection by the method of color and microcrystalloscopic reactions, thin-layer chromatography, UV-spectroscopy are offered in the thesis. The reseach of electrophoretic behavior of Bromhexine and Ambroxole has been carried out. The photoelectrocolorimetric, UV-spectrophotometric methods of Bromhexine and Ambroxole quantitative determination, as well as the extraction- photometric method of Bromhexine are elaborateded. The effective and expressive particular extractive methods of these preparations from biological material, for Bromhexine with the help chloroform Ambroxole with the help alcohol, are carried out. The extractive method of Bromhexine and Ambroxole from biological liquids of organism (blood, urine) are offered. On the basis of accomplished researches the scheme of Bromhexine and Ambroxole chemico-toxicological analysis in extracts from biological material is offered.

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