Dzyzenko T. Pathophysiological mechanisms of violations in liver's tissues and regulation of these before and after decompressing operation in case of obturation cholestasis

This thesis is devoted to a research of pathophysiological mechanisms of liver tissue morphofunctional condition violation during acute cholestasis and clearing up of the possibilities of their reparation after an operation of decompression and intensification after course injection of heptral. Is established, that activity of posttransmission modification of chromatin proteins from the liver cells nuclei reaction also will essentially change and their expressiveness and depth are in direct relation to a duration of cholestasis. As proved, that the depth of destructive shifts in a liver parenchime during cholestasis depends on a degree of disorganization of processes of posttransmission modification of the proteins. As clarified, that the negative shifts of occlusion both at molecular liver and on morphological largely looses after injection of the heptral. As determined that the leading role in regenerative processes of liver parenchyma after decompressive operation play mosttransmission modificationof chromatin proteins in liver cells nuclei reactions and injection of the heptral helps in amplification of these processes. As established that the heptral efficiency is the most indicative in cholestasis 24 hours duration both up to, and after operation.