Roman O. Synthesis, transformation and properties of 3,5-disybstituted 4-thiazolidones.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U001940

Thesis Registration Form

0403U001940.pdf

Applicant for

Roman Oleksandra Myronivna

Specialization

15.00.02 - Фармацевтична хімія та фармакогнозія

Date of defense

16-05-2003

Specialized Academic Board

Д 35.600.02

Danylo Halytsky Lviv National Medical University

Essay

Object - 3,5-disubstituted 4-thiazolidones; the purpose - synthesis of new 3,5-disubstituted 4-thiazolidones and related heterocyclic systems, search substances with high anti-inflammatory, antimicrobial activities and low toxity; methods - organic synthesis, NMR-, IR-, mas- spectroscopies, thin layer chromatograhy, virtual screening, traditional pharmacological screening, QSAR -2D analysis; novelty - the effective methods of synthesis of 3,5-disubstituted 2-thioxothiazolidine-4-ones, 2,4-thiazolidinediones, 2-methylidene-4-thiazolidones and thiazolothiopyranes are worked out. Group of lead-compounds with high anti-inflamatory and antimicrobial activities were chosen; the outcomes - positive decision about granting of Ukraine patent on invention (applikation №2001075528); there are introduced into scientific process of Institute of Molecular Biology and Genetics of National Academy of Ukraine (Kiev); into educational process of organic chemistry department of Ivan Franco Lviv National University and pharmaceutical chemistry department of Zaporizhzhya State Medical University; areas - pharmacy.

Thesis supervisor

Lesyk R.B.

Official opponents

Новіков В.П.
КоваленкоС.І.

Files

avtoreferat--finale-n.doc

avtoreferat--tytulka n.doc

dysert--Chapter-2--chapter 2n.doc

dysert--Chapter-2--ris2.1-2.2.doc

dysert--Chapter-2--ris2.3-2.4.doc

dysert--Chapter-2--table 2.5n.doc

dysert--Chapter-2--table2.2n.doc

dysert--Chapter-2--table2.3n.doc

dysert--Chapter-3--chapter 3n.doc

dysert--Chapter-3--ris3.1-3.2.doc

dysert--Chapter-3--ris3.3-3.4.doc

dysert--Chapter-3--ris3.5-3.6.doc

dysert--Chapter-3--table3.4n.doc

dysert--Chapter-3--table3.5n.doc

dysert--Chapter-3--table3.8n.doc

dysert--Chapter-3--table3.9n.doc

dysert--Chapter-4--chapter 4n.doc

dysert--Chapter-4--ris4.1-4.2.doc

dysert--Chapter-4--ris4.3-4.4.doc

dysert--Chapter-4--ris4.5-4.6.doc

dysert--Chapter-4--table4.2n.doc

dysert--Chapter-4--table4.4n.doc

dysert--Chapter-5--Table 5.4.doc

dysert--Chapter-5--chapter 5n.doc

dysert--Chapter-5--table 5.1.doc

dysert--Chapter-5--table 5.2.doc

dysert--Chapter-5--table 5.3.doc

dysert--VYSNOVKY n.doc

dysert--ZMIST.doc

dysert--chapter 1n.doc

dysert--dodatky--Dodatok B.doc

dysert--dodatky--Dodatok C.doc

dysert--dodatky--Dodatok D.doc

dysert--dodatky--Dodatok E.doc

dysert--dodatky--Dodatok F.doc

dysert--dodatky--dodatok A.doc

dysert--intoruction.doc

dysert--literatura n.doc

dysert--tytulka.doc

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