Perekhoda L. Synthesis and properties of 1,1,3-рrоpаnetreecаrbоnic and 1,1,3,3-рrоpаnetеtrаcаrbоnic acids amides

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U002512

Thesis Registration Form

0403U002512.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

20-06-2003

Specialized Academic Board

Д64.605.01

Essay

The new series of biologically active derivatives, such as anilides of crotonic and cinnamic acids, symmetric dianilides of malonic acid, amides of 2-methyl and 2-phenyl 1,1,3- рrоpаnetreecаrbоnic and 1,1,3,3-рrоpаnetеtrаcаrbоnic acids has been synthesized. The methods for the large-scale preparation of these substances were elaborated. The study of interaction N,N'-dibenzylamide of malonic acid with anilides of crotonic and cinnamic acid in reaction conditions Michael was performed. The structure of the compounds obtained was proved by methods NMR-, UV- and IR-spectroscopy.The biological activity of compounds synthesized was examined and the structure-activity relationships were developed. N,N?-dibenzyl-N??-(1-naphtyl)amide 2-methyl-1,1,3-рrоpаnethreecаrbоnic acids, which possesses high anticonvulsant activities, is undergoing an extensive pharmacological evaluation

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НАЦІОНАЛЬНИЙ ФАРМАЦЕВТИЧНИЙ УНІВЕРСИТЕТ.doc

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