Object of the study:: children with glomerulonephritis. Purpose of the study: T: children with glomerulonephritis. Methods of the investigation:To verify the diagnosis clinical examination and generally accepted laboratory studies were used. Blood plasma ET-1, NO and PL were determined. Immunological study included the study of phagocyte activity of neutrophils, the level of main clases of immunoglobulins (A, M, G), circulating immune complexes, lymphocyte subpopulations. Theoretical and practical results:TDetermining of ET-1 and NO2 in the blood plasma can be used as an additional criterion for prognosis of the course of the disease, the choice of rational therapeutic tactics and control of its efficacy. Investigation of ET-1 in acute glomerulonephritis allows to establish the presence of the disease progress and chronicity of the process before the appearacne of generally accepted clinical laboratory manifestations. For differential diagnosis of hematuric types of GN and toxicometabolic nephropathies it is reasinable to include ET-1 amount determining in the plan of examination. Administration of IACE in acute glomerulonephritis improves the treatment efficacy and prognosis. Novelty: Endothelium dysfunction was determined in various types of glomerulonephritis in children, its degree depending on the form and severity of the disease. It was shown that ET-1 could be a sign of inflammatory process in the kidneys and could be used as a marker of progression and further developemnt of the disease. It was established that NO prevailed in children with nephrotic syndrome with hematuria, hypertension and acute glomerulonephritis and ET-1 level was increased in other variants of glomerulonephritis. Correlation of ET-1 and NO2 in the blood and the parameters of the activity of the inflammatory process, blood coagulation system, nitrogen-excreting function of the kidneys and the degree of disturbances in lipid and phospholipid metabolism, parameters of specific and nonspecific protection were revealed. This allows to consider these mediators the mechanisms of non-immune mechanisms of development and progression of GN. Administration of IACE, which allow not only to normalize the blood pressure, to decrease proteinuria but also to improve the functional state of endothelin due to reduction of ET-1 and NO2 in the blood plasma, was substantiated. Degree of introduction:The findings of the research were introduced into the work of nephrology department of City Children's Clinical Hospital No. 16 (Kharkiv), City Children's Clinical Hospital No. 2 and 6 (Dnipropetrovsk), Children's Territory Medical Department (Evpatoria), nephrology departments of regional children's hospitals (Kharkiv), Donetsk, Zaporixhxhia, Ivano-Frankivsk, Chernivtsi). Sphere of application: medicine, pediatrics, nephrology.
