Terninko I. The chemico-toxicological investigation of Leponex

The thesis is devoted to chemico-toxicological analysis of antipsychotic preparation Leponex. In work the results of detection of Leponex by methods ТLС, HPLC, UV- and IR- spectroscopy are submitted. The extraction- photometric, UV-spectrophotometric and HPLC methods of Leponex quantitative determination are elaborateded. The conitions of Leponex extraction from aqueous solutions in dependence on pH medium have been studied. The comparative study of generally accepted in chemico-toxicological analysis of base substances extractive method related to Leponex is conducted. The expressive particular extractive methods of these preparation from biological material, with the help chloroform are carried out. The extractive method of Leponex from biological liquids of organism are offered. The distribution of the Leponex in bodies of the animals, poisoned with it is investigated. On the basis of accomplished researches the scheme Leponex chemico-toxicological analysis in extracts from biological material is offered.