Object of the study: Patients with acute and chronic hepatitis, cirrhosis of the liver, abscess of the liver, pancreas, spleen. Purpose of the study: Optimizing the diagnosis and control of treatment of the patients with hepatopancreatosplenic zone: hepatitis, cirrhosis and abscesses of the liver and adjacent organs by studying sonoscopic and sonographic changes and determining ultrasound diagnostic signs at evaluation of morphological changes in these diseases as well as at the treatment efficacy control. Methods of research: General clinical and laboratory instrumental, biochemical blood analysis, echography with determining linear and volume indices and the structure of the liver, pancreas, spleen and their vessels as well as blood flow in the portal and hepatic veins. Theoretical and practical results: Ultrasound signs of the diseases allow to determine the characteristics of morphological changes in acute and chronic hepatitis and liver cirrhosis as well as in purulent destructive diseases of theliver, spleen, and pancreas, whose diagnosis and differential diagnosis remains difficult. Non-invasive character and accessibility of the study in combination with high diagnostic value and possibility of numerous studies is the basis for its wide use in clinical hepatology as diagnostic and stratification tests for determining the process activity, characteristics of parenchymatous and vascular rearrangement and further changes due to therapeutic interventions. Sonomorphological criteria for diagnosis of diffuse acute and chronic liver diseases (hepatitis, cirrhosis) and purulent destructive diseases (pyogenic abscesses) were deter-mined. Methods of early diagnosis of abscess of the liver and spleen, highly active hepatitis, differential diagnosis of liver cir-rhosis, cholecystoduodenal fistula, the stage of liver peliosis, liver encephalopathy diagnosis, pancreas abscess diagnosis were worked out. Novelty: Characteristics of ultrasound signs of acute and chronic hepatitis, cirrhosis and abscess of the liverdepending on clinical manifestations of the disease: activity of the process, stage of the disease, presence of cirrhotic changes, were studied. The char-acteristics of ultrasound changes in the liver parenchyma in acute hepatitis and clinical forms of chronic hepatitis, stages of the disease, peculiarities of sonoscopic and sonographic changes in the liver parenchyma in chronic processes as well as localization and development of fibrotic processes, peculiarities of nodular rearrangement were determined with the purpose of differential diagnosis. Clinical ultrasound diagnostic signs of morphological changes at the stage of infiltration development were determined in purulent disease of the liver and pancreas. It was proved that the changes in the liver parenchyma in diffuse diseases (hepatitis and cir-rhosis) were accompanied by characteristic lesions of the vascular system: phlebitis of the hepatic veins at the stage of active acute hepatitis. The process chronicicty, especially cirrhosis development, manifests by reduction in intrahepatic veins visualization, decelera-tion of the blood flow in the portal circulation. Ultrasound criteria of compensated process and signs of decompensation were determined for liver cirrhosis, Regularities of ultrasound morphological changes in the liver structure at cirrhotic changes and shifting the process to cirrhosis development were established. Degree of introduction: The findings of the research were in-troduced into the clinical practice of medical establishments of Ukraine (Kharkiv and Kharkiv region) which is confirmed by the respective documents. The introduction resulted in increase of quality of the diagnosis of hepatobiliary diseases (hepatitis, cir-rhosis, abscesses of the liver, pancreas and spleen). Sphere of application: medicine, internal medicine.
