Maximyuk O. Modulation of HVA calcium channels in central neurons by intracellular sodium ions

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0404U001226

Thesis Registration Form

0404U001226.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

16-04-2004

Specialized Academic Board

Д26.198.01

Essay

It's established that increased concentration of Na+ ions in cytosolic media lead to potential-dependent inhibition and activation kinetic slowing of N- and P-type VDCC. QEHA peptide (specific free Gbg chelator) in 50 uM concentration eliminated all effects caused by increased cytosolic sodium. It's demonstrated that inhibition of HVA Ca2+ channels by sodium ions is mediated by heterotrimeric G-proteins.

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Files

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