Lyanenko L. Present-day approach to diagnostics and treatment of atypical condyloma of cervix of the uterus.

Thesis for degree of the candidate of medical science on speciality 14.01.01 - obstetrics and gynaecology. - O.O. Bogomolets National Medical University, Kyiv, 2004. The thesis is devoted to the improvement of diagnostics and complex therapy of atypical condiloma of cervix of the uterus (CU). Both sixty patients and fourty healthy women of the control group were observed for atypical comdiloma of CU induced by HPV. With the use of vaginographical and morphological methods traits of changes in vessels and tissue of the mucous tunic of CU with atypical comdiloma of CU were determined. This may be an evidence of the high proliferative activity of the epithelium affected by HPV and it may give warning of the high risk rate of malignant transformation. PCR results confirmed HPV of 16 and 18 types etiologic implication to induction of atypical comdiloma. Also presence of combined HPV1 and HPV2 infection in 68,8 % patients was revealed. After investigation of the immune status of patients with atypical comdiloma it was determined that desease course was accompanied by changes in cytokine profile of an organism. Consequently, in 75 % patients there was observed drastic reduction of ?- and ?-interferonogenic activity of peripheral blood cells accompained with background IFN concentrations in blood serum. Also there was observed hypersecretion of TNF accompained with exhaustion of reserve resources of cells producing this cytokine. High-performance method of atypical comdiloma of CU treatment is proposed, it forsees the use of combination that includes antiviral therapy, cryoablation and correction of immunity with hydrolase complex medications. Key words: cervix of the uterus, atypical comdiloma, human papilomavirus infection, hydrolase complex, pathogenesis, clinical course, diagnostics, complex therapy, immunotherapy.