Lyutenko N. Electrophilic reactions of b-aminovinyl trifluoromethyl ketones in the synthesis of potential bioactive compounds

b-Aminovinyl trifluoromethyl ketones. Studying of electrophilic reactions of their carbomoylation, aza-annulation, intramolecular electrophilic heterocyclization and research of physical and chemical properties of these compounds. Chemical synthesis, IR-and NMR-spectroscopy, chromatography. A range of new trifluoromethyl-containing compounds: sulphonylureas and vinylogous sulphonylureas (the perspective hypoglycemic agents) were obtained via carbamoylation. The aza-annulation reaction with chloroanhydrides of unsaturated carbonic acids gave the number of trifluoroacetyl analogues - structural components of known bioactive compounds which are used as excellent building blocks for the synthesis of new trifluoromethyl-containing pyperidones and pyrazoles. 3-Тrifluoroacetylquinolones (the fluorinated analogue of well-known antibacterial drugs) are obtained via intramolecular electrophilic acylation. Sphere of use - bioorganic and organic chemistry.