Shymkiv O. Ontogenetic Aspects of Separate Components of Pathogenesis of Ischemic Injuries in Rat’s Hippocamp

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0404U002037

Thesis Registration Form

0404U002037.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

21-05-2004

Specialized Academic Board

К 58.601.01

Essay

The dissertation deals with a study of the mechanisms of selective sensitivity to ischemia of hippocampal areas CA1, CA2, CA3 in animals aged from one to three month and pathogenetic aspects of the neuroprotective action of emoxipin under conditions of ischemic-reperfusing cerebral lesions. On the basis of studying the delayed sequelae of ischemia-reperfusion according to the intensity parameters of lipid peroxidation and oxidative modification of proteins, the activity of the enzymes of the antioxidant protection, the parameters of the fibrino- and proteolytic activity, the state of the marker enzymes of the membranes of Na+, K+-ATPase and 5?-nucleotidase, the reaction of the cyclic nucleotides (cAMP and cGMP) in hyppocampal areas CA1, CA2, CA3 of animals of different age groups, a conclusion has been arrived at to the effect that the selective sensitivity of the hippocampal areas to ischemic-reperfusing lesions, inherent to adult rats, is not complete in rats aged one month and continues its formingthroughout futher ontogenesis.

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