Bobeyko Y. A differentiated approach to the treatment of alopecia areata considering its clinical and pathogenic polymorphism, aminoacid spectrum and immune system disorders

The dissertation presents the research data of the investigation of special features of clinical symptoms and peculiarities of aminoacid blood serum spectrum changes and immune disorders in patients with alopecia areata (AA). The links between clinical characteristics of the disease with the accompanying pathology have been estimated and three pathogenical variants have been determined. The patients with infectious inflammatory variant developed the reduced total contents of replaceable and sulfur-containing aminoacids and increase of the irreplaceable aminoacids. In the patients with gastroenterological variant of AA the general quantity of aminoacids was insignificantly lower due to the reduced total concentration of irreplaceable aminoacids and considerable decrease of sulfur-containing aminoacids. In case of neurological and endocrine variant of AA a significant increase of general irreplaceable aminoacids level and decrease of sulfur-containing aminoacids was revealed. The immune disorders were characterized with T-lymphocyte depression and B-lymphocytes activation with low peripheric blood neutrophil phagocyte and metabolic activity. A differentiated prescription of aminoacid-containing drugs with metabolic action (oktamin plus, glutaminic acid) with immunoactive agent erbisol resulted in the beneficial clinical outcome in 81.5 per cent of patients, 1.5 fold reduced duration of the treatment and 2.5 fold decreased level of recurrencies compared to the conventional treatment.