Zakharov V. Disturbed microcirculation in an initial stage of an Explosive Mine Trauma and possible ways of its correction.

A research object is pathogeny of the Сombined Explosive Mine Trauma and separate its components; purpose: to study the patogenetic features of disturbed microcirculation in case of occurring of Explosive Mine Trauma and action of its separate components - mechanical, thermal and toxic, and the GABA-ergic system activation with the purpose of correction of the noted disorders; methods - the methods of design of the Combined Mine Trauma and separate its components on experimental animals in the special devices were used, that allow to make the experiment in laboratory conditions; theoretical and practical results - the patogenetic features of the disturbed microcirculation were studied at an Explosive Mine Trauma and action of its separate components (mechanical, thermal and toxic), and the GABA-ergic system activation with the purpose of correction of the noted disorders; novelty - it is first set that the protracted action of industrial condition on the organism determines the weight of next microcirculatory disorders in case of occurring Combined Trauma and at overwhelming action of separate its components; it is first shown that on the initial stage of development trauma the patogenetic divergences of microcirculation are more expressed at Complicated Trauma; first shown action of benzodiazepines on early microcirculatory disorders after an Explosive Mine Trauma; it is inculcated on the departments of pathological physiology in Donetsk, Zaporozhian, Lugansk State Medical Universities, Military Medicine department of the Donetsk State Medical University, Institute of Exigent and Renewable Surgery named after V. K. Gusak MSA of Ukraine, Research Institute of Traumatology and Orthopaedy in Donetsk; sphere of use - medicine (pathological physiology).