Tkachenko V. The chemico-toxicological investigation of Loperamide

The thesis is devoted to chemico-toxicological analysis of preparation Loperamide. In work the results of detection of Loperamide by methods ТLС, HPLC, UV- and IR- spectroscopy are submitted. The extraction-photometric, UV-spectrophotometric, ionometric and HPLC methods of Loperamide quantitative determination are elaborateded. The conitions of Loperamide extraction from aqueous solutions in dependence on pH medium have been studied. The comparative study of generally accepted in chemico-toxicological analysis of base substances extractive method related to Loperamide is conducted. The expressive particular extractive methods of these preparation from biological material, with the help acetonitrile are carried out. The extractive method of Loperamide from biological liquids of organism are offered. The distribution of the Loperamide in bodies of the animals, poisoned with it is investigated. On the basis of accomplished researches the scheme Loperamide chemico-toxicological analysis in extracts from biological material is offered.